Independent overexpression of the subunits of translation elongation factor complex eEF1H in human lung cancer.

Background: The constituents of stable multiprotein complexes are known to dissociate from the complex to play independent regulatory roles. The components of translation elongation complex eEF1H (eEF1A, eEF1Bα, eEF1Bβ, eEF1Bγ) were found overexpressed in different cancers. To gain the knowledge about novel cancer-related translational mechanisms we intended to reveal whether eEF1H exists as a single unit or independent subunits in different human cancers.

[Diagnosis and treatment of primary mediastinal angiosarcoma].

The results of treatment of 23 patients, suffering primary angiosarcoma (AS), and 7--having mediastinal hemangiopericytoma, were analyzed. Primary mediastinal AS constitutes a quite rare tumor, for its recognition it is necessary to do differential diagnosis from tumors with possible localization in anterior mediastinum. AS differs by more aggressive course and, accordingly, by poorer results of treatment and poorer prognosis as well.

[Complex treatment of oral mucosa cancer].

The analysis of the results of complex treatment of 58 patients with oral mucosa cancer was conducted. In the main group of 20 patients used a method developed by the authors comprehensive treatment, including chemoradiotherapy (CRT), cryodestruction (CD) of the tumor, followed by 24 hours of local microwave hyperthermia. In the control group of 38 patients with complex treatment consisted of a CRT and a CD of the tumor.

[Mixed monolayers of amphiphile-modified nucleic bases and diynoic acids. I. Phase states at air-water interface and in Langmuir-Blodgett films].

Monolayers of amphiphile-modified nucleic bases with diynoic acid were obtained and characterized. The synthesized nucleic bases contained in the monolayer complementarily bind the nucleotide molecules contained in the aqueous subphase, and the structure of the resulting monolayers can be fixed by the photopolymerization of diynoic acid. The resulting monolayer exemplifies a novel type of model systems for investigating molecular recognition at the surface of biological membranes.