Publications by authors named "V V Tarasova"
Evaluation of an incidentally discovered indeterminate thyroid nodule (TN) in a previously healthy 59-year female led to diagnosis of thyroid paraganglioma (TPGL) and subsequently hereditary succinate dehydrogenase complex subunit D (-related multifocal head and neck paragangliomas (PGLs). An ultrasound-guided fine needle aspiration (FNA) biopsy of the 1.7-cm TN was nondiagnostic and core biopsy was suspicious for papillary thyroid carcinoma.
View Article and Find Full Text PDFArticle Synopsis
- - The text discusses the challenges in treating thyroid cancer due to limited targeted therapies and the need for identifying specific genomic abnormalities, with plasma-based ctDNA sequencing emerging as a valuable detection method.
- - A study analyzing 1,094 thyroid cancer patients utilized Guardant360 plasma-NGS to find genomic alterations across various subtypes, revealing that 78.3% had one or more mutations, with significant findings in different cancer types.
- - The analysis showed that mutations in the gene were prevalent across various thyroid cancer types, particularly in anaplastic and papillary thyroid cancers, and indicated that the blood tumor mutation burden was notably higher in anaplastic thyroid cancer.
The head and neck region is one of the anatomic sites commonly afflicted by cancer, with ~1.5 million new diagnoses reported worldwide in 2020 alone. Remarkable progress has been made in understanding the underlying disease mechanisms, personalizing care based on each tumor's individual molecular characteristics, and even therapeutically exploiting the inherent vulnerabilities of these neoplasms.
View Article and Find Full Text PDFObjective: To determine the proportion of aspirates reclassified into each Bethesda category and to assess the rates of malignancy in each of them on repeat fine-needle aspiration biopsy (RFNA) following an AUS/FLUS diagnosis.
Design: Systematic review and meta-analysis.
Methods: On February 2019, Pubmed/MEDLINE, EMBASE, WoS, and the Cochrane Library were searched for articles published from January 1, 2007.
Emulsion fat products due to the presence of the aqueous phase are more prone to oxidative damage than pure oils and fats, which requires the use of antioxidants. Based on a social request for the use of natural antioxidants in the food industry, tocopherols, their mixtures, as well as ascorbic acid are widespread. However, most natural antioxidants (vitamins, plant extracts) have lower antioxidant activity in fats than synthetic ones and require more incorporation into the product, which can negatively affect its organoleptic properties and the cost of the finished emulsion fat product.
View Article and Find Full Text PDF