NO-ergic neurons of the cervical nucleus of the rat brain in normal conditions and after administration of opiates.

Histochemical reactions for NADPH-diaphorase (NADPH-d) were used to study the dynamics of NO synthesis activity in the cervical nuclei of the rat brain after i.v. administration of morphine hydrochloride.

[NO-ergic rat brain commissural neurons in the norm and during opiate administration].

Using histochemical reaction demonstrating NADPH-diaphorase (NADPH-d), the dynamics of NO synthesis was studied in the rat brain raphe nuclei following intravenous injection of morphine hydrochloride. In normal conditions NADPH-d activity was demonstrated in neurons of all raphe nuclei. Acute and chronic administration of morphine in different doses (0.

Dynamics of NADPH diaphorase activity in raphe neurons during chronic treatment with opiates.

Systemic administration of diacetylmorphine considerably reduced the number of NADPH diaphorase-positive (NO-synthesizing) neurons in rat brain raphe nuclei. This effect was blocked by naloxone. In animals with the withdrawal syndrome NO-ergic activity in raphe neurons increased and surpassed the normal.

[Bleomycetin antitumor activity in relation to solid mouse tumors].

The antitumor activity of bleomycetin or bleomycin A5 was studied with respect to sarcoma 180, Garding-Passey melanoma, cervical carcinoma CC-5 and lymphosarcoma L10-1. Bleomycetin showed a high selective effect on the solid form of sarcoma 180. Its activity against Garding-Passeys melanoma and cervical carcinoma CC-5 was lower.