Publications by authors named "V V Saburov"
Combined proton-neutron therapy can be the best opportunity for neutron radiation therapy due to highly conformal proton irradiation and high relative biological effectiveness of neutrons. The study compares 4 schemes of sequential in vitro exposure of Chinese hamster fibrosarcoma cells B14-150 to 14.5 MeV neutrons and a scanning beam of protons.
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- The study focuses on how plants respond to extreme conditions like microgravity and radiation, which is important for space exploration and improving plant resilience in outer space.
- Researchers created a 3D clinostat to replicate microgravity conditions and used proton irradiation to simulate space conditions, studying the effects on plant seeds from the Chernobyl exclusion zone.
- Results showed that one plant type was resilient to these conditions, while others experienced inhibited photosynthesis; findings and tools developed are available for further research in space biology.
Objective: Traditional cell-based radiobiological methods are inadequate for assessing the toxicity of ionizing radiation exposure in relation to the microstructure of the extracellular matrix. Organotypic tissue slices preserve the spatial organization observed in vivo, making the tissue easily accessible for visualization and staining. This study aims to explore the use of fluorescence microscopy of physiologically compatible 3D tissue cultures to assess the effects of ionizing radiation.
View Article and Find Full Text PDFComparative Analysis of the Effect of Gamma-, Electron, and Proton Irradiation on Transcriptomic Profile of L. Seedlings: In Search for Molecular Contributors to Abiotic Stress Resilience.
Plants (Basel)
January 2024
Article Synopsis
- - The study focuses on developing crop adaptation strategies in response to climate change, specifically through investigating barley's reaction to ionizing radiation as a means to understand stress resilience.
- - Researchers identified 553 genes that were upregulated and 124 downregulated in barley seedlings after exposure to different types of radiation, with the highest activity seen in samples exposed to electrons.
- - Key genes relating to stress responses, such as those involved in DNA repair, ROS response, and photosynthesis, were significantly activated, suggesting that understanding these pathways could enhance plant stress tolerance in agriculture.
We studied the effects of single and combined action of protons and carbon ions C on the pool of MCF-7 human breast cancer stem cells. Single irradiation with a beam of protons or carbon ions had no significant effects on the relative number of cancer stem cells (CSC). The effects of combined irradiation in a total equieffective dose of 4 Gy depended on the sequence of exposure to ionizing radiations: the relative number of CSC did not change after irradiation with carbon ions and then with protons, but increased in the case of the reverse sequence.
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