A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor-specificity.

P-cadherin (pCAD) and LI-cadherin (CDH17) are cell-surface proteins belonging to the cadherin superfamily that are both highly expressed in colorectal cancer. This co-expression profile presents a novel and attractive opportunity for a dual targeting approach using an antibody-drug conjugate (ADC). In this study, we used a unique avidity-driven screening approach to generate pCAD x CDH17 bispecific antibodies that selectively target cells expressing both antigens over cells expressing only pCAD or only CDH17.

Double Burden of Malnutrition Among Pregnant Women in Rural Jharkhand: Evidence From a Cross-Sectional Study.

Introduction: The nutritional status of pregnant women is a very important aspect of maternal and antenatal care, as malnutrition is detrimental to both the mother and the foetus. This study tries to assess the scale of the double burden of malnutrition in a rural setting in India.

Methods: A cross-sectional study was conducted on 337 pregnant women to assess the nutritional status of pregnant women using Body Mass Index and dietary intake.

Unveiling predictors of developmental delay among under-fives: Insights from a community study.

Introduction: The development of a child is a crucial factor that ultimately affects the quality of life of children. Developmental delay can be prevented if it is identified early and adequate attention is given from the start.

Methodology: A cross-sectional analytical study was conducted between December and November 2022 on 450 children by multistage cluster sampling in the Ormanjhi block of Ranchi, Jharkhand.

Breathing orchestrates synchronization of sleep oscillations in the human hippocampus.

Nested sleep oscillations, emerging from asynchronous states in coordinated bursts, are critical for memory consolidation. Whether these bursts emerge intrinsically or from an underlying rhythm is unknown. Here, we show a previously undescribed respiratory-driven oscillation in the human hippocampus that couples with cardinal sleep oscillations.

A Qualitative Study on the Burden of Nonadherence to Antiretroviral Therapy Among People Living With HIV/AIDS in Jharkhand, India.

Background: Adherence to antiretroviral therapy (ART) is the most important factor in the management of human immunodeficiency virus (HIV). This study examines the level of nonadherence to ART and the predictors of interventions to improve ART adherence in Jharkhand, a state with a predominance of tribes.

Methods: The present study was conducted at the ART center, Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand.