Intratumoural injection of gamma leinolenic acid in malignant gliomas.

In vitro and in vivo studies have shown that gamma-leinolenic acid (GLA) can selectively kill tumour cells without harming normal cells. In view of this we have investigated the effect of intratumoural injection of GLA in intracranial gliomas, after reconfirmation of the safety of the drug on normal dog brain (n = 3). Fourteen patients underwent neurosurgical decompression along with placement of a catheter into the tumour bed.