Acetylsalicylic acid as a modulator of neutrophil peroxidase system.

Effect of acetylsalycilic acid (aspirin; Ron-Pulenk) on activity of mouse neutrophil peroxydase system was investigated. Using luminol-dependent chemiluminscence and cytochemical methods we demonstrated that neutrophil peroxydase system in mice receiving aspirin for 14 days is probably determined by stimulation of myeloperoxydase synthesis.

Clofibrate and dalargin increase luminol-dependent chemiluminescence of mouse blood.

The effects of hypolipidemic drug clofibrate and polypeptide dalargin on activity of the neutrophil peroxidase system in mice were studied using the method of luminol-enhanced chemiluminescence. Clofibrate and dalargin increased the chemiluminescence of mouse whole blood. Their combined use several-fold potentiated this effect.

Effect of some xenobiotics on oxidative metabolism of human blood neutrophils.

The effect of SO3(2-), S(2-), NOs(-), and NH4(+) on activity of the peroxidase-hydrogen peroxide system in human peripheral blood neutrophils was studied by the cytochemical method. We showed that the effect of these xenobiotics on neutrophils is similar to that on plants.

[Toxic effect of heavy metals on human blood neutrophils].

Activity of the peroxidase-hydrogen peroxide system is proposed as a biological marker of ecological risk of heavy metal contamination of the environment. The effect of lead, copper, mercury, and cadmium ions on peroxidase system activity in human peripheral blood neutrophils was studied using cytochemical methods. A possible mechanism of suppression of peroxidase system activity by metal ions is discussed.

[Intracellular transformation of phagosomes].

The transformation of nascent phagosomes into forms capable of interacting with antimicrobial organelles of phagocytes, peroxisomes, depends on certain interactions between phagosomes and other vacuolar organelles. Phagosomes repeatedly interact with early and late endosomes through temporary contacts, which allows them to gain and lose complex sets of proteins. In addition, certain polypeptides are eliminated from phagosomes through recycling.