[Treatment of patients with damage of the hip joint and proximal section of the femur in polytrauma resulting in shock].

The research of efficiency of operative and conservative methods of treatment was conducted in 426 patients with damage of the hip joint, brought to the Dzhanelidze Research Institute of Emergency Medicine, Saint-Petersburg with severe mechanical shockogeneous trauma, resulted in shock since 1997 till 2008. The operative interventions were performed using the methods suggested by the authors. The results were estimated by Harris scale and showed significant advantages of operative methods over conservative ones.

[Practical value of certain prognostic scales in wound dystrophy].

The authors gave comparative characteristics of the data available in literature and the scales of evaluation of the severity and prognosis of wound dystrophy used by them.

[Complex influence of pharmacological agents on degenerative processes in brain of Drosophila melanogaster mutants].

A scheme of complex administration of drugs in the order neuroprotector + neuroactivator + neuroretarder for the treatment of neurodegenerative processes in the brain has been elaborated and tested on a model object representing neurodegenerative mutants of Drosophila melanogaster. The appearance of changes in the brain was delayed when drugs were used separately: donepezil hydrochloride (arisept), 10 - 11 days, epinephrine and nimodipine, 1 - 2 days. The treatment of flies with the same drugs in the order arisept + epinephrine + nimodipine leads to the complete regeneration of D.

[Effect of adement preparation and its low-molecular fractions on development of neurodegenerative processes in Drosophila melanogaster mutants].

Neuroprotective and neuroactivative properties of Adement preparations and the influence of Adement and its low-molecular fractions (9-10 Da, 4-6 Da, 1-2 Da) on dinamics of neurodegenerations, viability and lifetime of Drosophila melanogaster mutants with changes of brain structures have been investigated. It was shown that Adement as neuroprotector causes the delay of neurodegenerative changes by 10-15 days and increase of lifetime by 14%. None of the studied low-molecular fractions did not reveal the better effect on these indices than the total preparation.

[Genetic analysis of X-chromosome neurodegenerative mutants of Drosophila melanogaster induced by ethyl methansulfonate and nitrosoethylurea].

In a series of Drosophila mutants with changes in the brain structure, some characters (reduced life span, behavioral changes, and neuronal loss in various brain regions) resemble symptoms observed in human patients with neurodegenerative diseases. In addition, similar specific phenotypes shared by different species suggest that common mechanisms underlie degeneration of their nerve cell. This study reports the results of a genetic analysis of new X-chromosome mutants with neurodegenerative changes in brain structure, which were induced by chemical mutagenesis.