[Antiviral effect of various oligonucleotide derivatives, complementary to tick-born encephalitis virus RNA].

Antiviral effect of two nucleotides complementary to tick-borne encephalitis (TBE) virus genome and their derivatives was compared to that of noncomplementary oligonucleotides. All the tested reagents influenced TBE multiplication in cell culture, this manifesting by various degrees of suppression of the cytopathic effect of the virus. Intact oligonucleotides, both complementary and noncomplementary to TBE, reduced virus titer by 2-4 orders, whatever the concentration of oligonucleotide.