Short-term systems to assess thiophosphoryl chloride standards.

The rat acute oral LD50 value of PSCl3 is 750 mg per kg body weight. A rat 90-day oral feeding study at dose levels of 7.5 mg (P1) and 37.

The "concrete" histological diagnosis of cerebral tumours of neuroectodermic origin.

The "concrete" histological criteria for establishing the benignity or malignancy of cerebral tumours of neuroectodermic origin (gliomas and medulloblastomas, respectively granulocytomas) may be thus synthetized: 1) the benign tumours have a fibrocellular structure, the neoplastic cells being relatively monomorphous; vascular hyperplasia is absent, as well as necrotic and hemorrhagic foci; 2) the malignant tumours are hyper- and polymorphocellular, the fibrillar component being reduced or absent; vascular hyperplasia as well as the presence of necrotic and/or hemorrhagic foci is a constant characteristic; the tumoral cells often infiltrate the perivascular spaces.

The "concrete" histo-cytological diagnosis of noninfiltrative cancer.

The diagnosis of noninfiltrative carcinomas (intraepithelial carcinoma, respectively intramucosal adenocarcinoma) is based on the existence of architectural modifications of the stratified squamous epithelia (the skin included) and of glandular structures. The architectural alterations are associated with cellular, respectively nucleo-cytoplasmic changes. The most useful cellular modifications for the diagnosis of the noninfiltrative malignant process of epithelial origin are: the cellular pleomorphism (anisocytosis and especially anisokaryosis), large nuclei in comparison with cell dimensions determining modifications of the nucleo-cytoplasmic ratio, the presence of hypertrophic nucleoli, respectively giant and/or multiple nucleoli with the change of the nucleolo-nuclear ratio in favour of the nucleolus, a large percentage of mitoses (more than 20 mitoses per thousand cells), respectively more than 4 mitoses in the microscopic field at a high magnification.

Effect of cadmium chloride on adrenal function in the white rat.

Wistar female rats were given 0.5 mgCd+2/kg b.w.