Publications by authors named "V V Novitsky"
Article Synopsis
- The study examines HIV clustering rates in Rhode Island from 1991 to 2023, emphasizing how tracking these rates can enhance understanding and management of local HIV epidemics.
- Researchers utilized an academic-public health partnership to analyze molecular clusters of HIV-1, revealing a significant increase in overall clustering rates from 7% to 46% over the 32 years.
- The findings suggest a shift towards a more concentrated epidemic, underscoring the need for targeted interventions aimed at preventing new HIV transmissions among specific populations.
Low prevalence of archived integrase strand transfer inhibitors resistance associated mutations in Botswana before the roll out of dolutegravir based first line antiretroviral therapy.
Front Microbiol
October 2024
Article Synopsis
- - The study assessed the prevalence of drug resistance mutations (DRMs) to integrase strand transfer inhibitors (INSTIs) just before Botswana switched to dolutegravir (DTG) for first-line HIV treatment in 2016, analyzing over 5,000 HIV-1 sequences from various individuals.
- - Results indicated that the overall prevalence of significant INSTI DRMs was 1.11%, with higher rates found in those who had not received antiretroviral treatment (ART-naïve individuals) compared to those who had (ART-experienced individuals).
- - Notable mutations associated with INSTI resistance included E138K and G140R, but high-level resistance to newer drugs like dolutegravir
Background: Studying viral sequences can provide insights into the structure of host contact networks through which the virus is transmitted. Uncovering the population structure of the HIV-1 epidemic in Botswana will help optimise public health interventions and may identify hidden sub-epidemics. We sought to determine the phylodynamic structure of the Botswana HIV-1 epidemic from viral sequence genetic data.
View Article and Find Full Text PDFBackground: Human immunodeficiency virus (HIV) remains a global challenge and novel measures for transmission disruption are needed. Contact tracing is limited by reluctance or inability of newly diagnosed individuals to name at-risk contacts. Molecular cluster analysis is mostly used for outbreak investigations, and its role in routine public health activities remains uncertain.
View Article and Find Full Text PDFBackground: The extent of the SARS-CoV-2 short-term evolution under Remdesivir (RDV) exposure and whether it varies across different upper respiratory compartments are not fully understood.
Methods: Patients hospitalized for COVID-19, with or without RDV therapy, were enrolled and completed up to three visits, in which they provided specimens from four respiratory compartments. Near full-length genome SARS-CoV-2 sequences were obtained from viral RNA, standard lineage and variant assignments were performed, and viral mutations in the RNA-dependent RNA polymerase (RdRp) region-the RDV target gene-were detected and compared between participants with and without RDV, across the four compartments, within participants across visits, and versus a larger sequence dataset.