[The optimization of the detection of tumors of the organs of the hepatobiliopancreatic area by a combination of the ultrasonic study method and of the determination of tumor markers in the blood serum].

To find out new possibilities of improving the diagnosis of tumors of the hepatobiliopancreatic area, comparative assessment was made of the efficacy of ultrasonography and detection of oncomarkers (carcinoembryonic antigen and carbohydrate antigen CA-19-9) in blood serum of patients with suspected carcinoma and metastatic injury to the liver, the biliary system and pancreas. Analysis of the results has shown that echography is highly informative in the diagnosis of the given pathology type. However, in some cases, particularly in those where ultrasonography is impeded or else its results are inconclusive, it is advisable that the concentration of oncomarkers (preferably of CA-19-9) be measured additionally in blood serum, with those oncomarkers producing the highest effect in tumors of the biliary system and pancreas.

[Experimental studies of the possibilities of radioimmunodetection of cancer of the large intestine by subcutaneous administration of iodinated antibodies to intestinal antigen beta1-MA].

131I- and 125I-labeled rabbit antibodies (AB) to the specific human intestinal beta 1MA were administered sc and iv to nude mice xenografts of human colon carcinoma. A study was made of the pharmacokinetics of labeled AB in the recipients' organs and tissues, measuring the radioactivity of tissue specimens on days 2, 3, 4 and 7 after injection with a gamma-counter, calculating specific radioactivity and accumulation indices. Tumors were visualized with a gamma-camera and a scanner.

[The concentration of carcinoembryonic antigen and carbohydrate antigen Ca-19-9 in the blood serum in cancerous diseases of the gastrointestinal tract].

The results of comparative investigation of 266 cancer patients, 44 patients with benign G. I. tract diseases and 66 healthy subjects using 2 tumor markers (CEA and Ca-19-9) showed the diagnostic value of both methods, not exceeding 38-42%.

[Experimental visualization of human colon cancer using 131I-antibodies to intestinal beta 1 MA antigen].

131I-antibodies to human beta 1 colonic antigen was administered i.v. to nude mice with transplanted human colon carcinoma.