[Therapeutic targets of adolescent depression with attenuated symptoms of schizophrenia].

Objective: Identification of therapeutic targets in the treatment of adolescent depression with attenuated symptoms of schizophrenia and assessment of the effectiveness of therapeutic interventions.

Material And Methods: One hundred and twenty-three patients (mean age 19.6±2.

[The relationship between inflammatory markers, fatigue, and effort-based decision-making in patients at clinical high risk for psychosis].

Objective: To evaluate the associations between peripheral levels of inflammatory markers and willingness to exert effort in individuals at clinical high risk for psychosis (CHR-P) and a role of fatigue as a mediator of these associations.

Material And Methods: Forty-nine young men admitted for a depressive episode, who met the criteria for CHR-P, had pre-treatment blood tests to determine levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukins IL-6, IL-8 and IL-10. After treatment and normalization of their condition, they completed the EEfRT task of willingness to exert physical effort to receive monetary reward and filled out the Fatigue Assessment Scale (FAS-10).

[Willingness to expend effort for rewards in individuals at clinical high-risk for psychosis: a relationship with the severity and stability of negative symptoms].

Objective: To identify the deficit in willingness to expend effort and its association with negative symptoms in the high-risk for psychosis (CHR) group.

Material And Methods: The study included young men: 45 patients, who met CHR criteria and were treated for a depressive episode, and 15 controls. All subjects completed a modified version of the Effort Expenditure for Rewards Task (EEfRT).

[Application of the biofeedback method in the therapy of depression].

In order to systematize the modern literature data on the effectiveness of biofeedback in the treatment of patients with depressive disorders, clinical efficacy and prospects for use in psychiatric practice, publications in the MEDLINE / PubMed, eLibrary databases from 2013 to 2023, as well as relevant references in the reference lists of the analyzed articles, were selected by the keywords «biofeedback», «depression», «depression therapy», «electroencephalogram», «non-drug treatments for depression». The analysis of data has shown that the biofeedback method demonstrates a certain therapeutic potential in the treatment of depression. It can be used to augment therapy in case of insufficient therapeutic effect, with low patient compliance, as well as poor tolerability of psychopharmacotherapy and in the presence of residual symptoms after pharmacological treatment.

[Features of inflammatory reactions in patients with juvenile depression with a clinically high risk of psychosis].

Objective: To determine the levels of pro-inflammatory and anti-inflammatory cytokines and inflammatory markers such as C-reactive protein, leukocyte elastase, α1-proteinase inhibitor, autoantibodies to neuroantigens in the blood of patients with adolescent depression with clinical high risk for psychosis (CHR-P) and to study the relation of these biological markers to the features of psychopathological symptomatology of the patients.

Material And Methods: Eighty young adults, aged 16-24 years, with the first depressive episode (F32.1-2, F32.