[On the way to national reference system of laboratory medicine].

The application of standard samples and reference techniques of implementation of measurements is needed for a valid support of reliability of analyses applied in clinical diagnostic laboratories. They play role of landmarks under metrologic monitoring, calibration of devices and control of quality of results. The article presents analysis of shortcomings interfering with formation of national reference system in Russia harmonized with possibilities provided by international organizations.

[The innovative approach to improvement of accuracy of cytological analysis: application of intrascopic technology].

The article presents information concerning development of device Cell-CTtm by the American specialists to implement cytological analysis of 3D images of cells using technology of computer tomography by means of visible photons and not x-rays beams. Since density of single cell is insufficient for x-ray analysis. The isotropic resolution of Cell-Cttm permits receiving highly contrast and neatly separating signal from noise image of cell structures in 200 nm range.

[Optimization of healthcare expenditures, centralization of laboratory determinations and laboratory information accessibility].

The optimization of money expenditure for healthcare is leading to the reorganization of the structure of medical organizations, to reducing of small establishments, to centralization of laboratory analyses with cessation of their performing in some hospitals and out patient offices. This tendency is based on medical (enlargement of laboratory tests spectrum) and economical (high productivity, relative reducing of net cost of laboratory determinations) reasons. But the repercussions of switch-over to centralization of laboratory analyses performance must be evaluated from the position of laboratory information accessibility tacking in account the need in express analyses for patient, situated on territories outlying from the centralized laboratory.

[On the means of securing analytical reliability of laboratory results].

The article is composed in the form of discussion with authors of another article published in the same issue of journal. The publication considers factors impacting analytical quality of results of clinical laboratory analyses. The cases in question are content of normative documents in force, expedience to complete them with more specific requirements to producers of laboratory analysis tools and recommendations for laboratories on implementation of verification of characteristics of techniques and medical tools for diagnostic in vitro.

[The requirements of standard and conditions of interchangeability of medical articles].

The article deals with possibility to apply specific approaches under evaluation of interchangeability of medical articles for laboratory analysis. The development of standardized analytical technologies of laboratory medicine and formulation of requirements of standards addressed to manufacturers of medical articles the clinically validated requirements are to be followed. These requirements include sensitivity and specificity of techniques, accuracy and precision of research results, stability of reagents' quality in particular conditions of their transportation and storage.