Publications by authors named "V V McCutcheon"
Background: Associations between childhood trauma, neurodevelopment, alcohol use disorder (AUD), and posttraumatic stress disorder (PTSD) are understudied during adolescence.
Methods: Using 1652 participants (51.75% female, baseline = 14.
Article Synopsis
- The study investigates the genetic factors related to various alcohol use behaviors (AUBs) by analyzing large samples from the UK Biobank, recognizing the complexity and diversity of AUBs in its approach.
- Researchers identified four latent genetic factors tied to AUBs, including how people consume alcohol and their drinking preferences, suggesting distinct genetic associations for each factor.
- The findings emphasize the need for deep phenotyping and more sophisticated methods to better understand the genetics of AUBs, which remain poorly understood despite large sample sizes in previous genome-wide studies.
Recent conceptualizations frame addiction recovery as a complex process involving changes across behavioral, physical, psychological, and social domains. These broad conceptualizations can be difficult to apply directly to research, making detailed models of individual dimensions necessary to guide empirical work and subsequent clinical interventions. We used Kelly and Hoeppner's (2015) biaxial formulation of recovery as a basis for a detailed examination of social processes in recovery using social network approaches.
View Article and Find Full Text PDFBackground: In the United States, ~50% of individuals who meet criteria for alcohol use disorder (AUD) during their lifetimes do not remit. We previously reported that a polygenic score for AUD (PGS ) was positively associated with AUD severity as measured by DSM-5 lifetime criterion count, and AUD severity was negatively associated with remission. Thus, we hypothesized that PGS would be negatively associated with remission.
View Article and Find Full Text PDFImportance: Current Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5) diagnoses of substance use disorders rely on criterion count-based approaches, disregarding severity grading indexed by individual criteria.
Objective: To examine correlates of alcohol use disorder (AUD) across count-based severity groups (ie, mild, moderate, mild-to-moderate, severe), identify specific diagnostic criteria indicative of greater severity, and evaluate whether specific criteria within mild-to-moderate AUD differentiate across relevant correlates and manifest in greater hazards of severe AUD development.
Design, Setting, And Participants: This cohort study involved 2 cohorts from the family-based Collaborative Study on the Genetics of Alcoholism (COGA) with 7 sites across the United States: cross-sectional (assessed 1991-2005) and longitudinal (assessed 2004-2019).