[Immune homeostasis impairment in acute carbon tetrachloride intoxicated rats corrected by administration of tocopherol acetate and unithiol].

The results of experiments on noninbred albino rats showed that the acute intoxication with carbon tetrachloride (CT) at a dose of 1 LD50 reduced the parameters of cellular immune response and function of Th1 cells more significantly than the levels of humoral immune response and Th2-lymphocyte function, decreases the blood content of immunoregulatory cytokines IFN-g, IL-2, IL-4 and anti-inflammatory cytokine IL-13, while not changing the concentration of anti-inflammatory cytokine IL-10 and increasing the concentration of pro-inflammatory cytokine IL-6. The application of unithiol, tocopherol acetate, and combinations partially restores the parameters examined. The combined effects of drugs during intoxication with CT does not exceed their separate action.

[The effect of anabasine on mortality and concentration of proinflammatory cytokines in blood of mice at early stage of sepsis].

It was established in experiments on noninbred mice that activation of α-7n acetylcholine receptors (α-7n AChR) by anabasine in single doses of 1.0 and 5.0 mg/kg for 2 h before modeling sepsis (intraperitoneal injection of E.

[Microcirculation in the injured spleen by different operations in children].

43 children were operated on spleen injury: 14 were splenectomized; 29 splenectomy were completed with partial spleen tissue autotransplantation into the omentum. Changes of homeostatic system, hemoreology and immune status were followed up within 1 year after the operation, Connections between the type of the operation performed and the listed above changes were followed.

[Changes in the immune status of patients operated for splenic lesions in the late postoperative period and their relation to the development of complications].

This analysis of changes in the immune status of patients operated for splenic lesions is based on the observations of 126 subjects. Fifty of them underwent autolientransplantation and 26 conservative surgery. The main parameters of humoral and cellular immunity were measured along with changes in the microflora.

[Surgical strategy for iatrogenic injuries of the spleen].

A retrospective investigation of 1226 case histories of patients operated on the stomach and duodenum was made. Organ-saving operations using laser technique were assessed. The main cause of injuries to the spleen during operation was traction of the stomach when mobilizing it.