Publications by authors named "V V Maksimova"
Non-communicable chronic diseases (NCDs) are most commonly characterized by age-related loss of homeostasis and/or by cumulative exposures to environmental factors, which lead to low-grade sustained generation of reactive oxygen species (ROS), chronic inflammation and metabolic imbalance. Nuclear factor erythroid 2-like 2 (NRF2) is a basic leucine-zipper transcription factor that regulates the cellular redox homeostasis. NRF2 controls the expression of more than 250 human genes that share in their regulatory regions a cis-acting enhancer termed the antioxidant response element (ARE).
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- Ribavirin and its modified versions were found to have a significant effect on inhibiting the growth of cancer cells, particularly leukemia cells.
- Researchers synthesized several derivatives of ribavirin, specifically targeting their structural positions to evaluate their antiproliferative and antimicrobial properties, showing that some were effective against both Gram-positive and Gram-negative bacteria.
- The most promising derivative, n-decyloxymethyl, was shown to kill leukemia cells at low doses by disrupting cell cycle progression and potentially inhibiting critical cellular processes involved in cancer growth.
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- * Current treatments primarily involve surgical resection for localized cases, with chemotherapy and radiotherapy as adjuncts, while targeted therapies remain limited.
- * There is a growing interest in exploring molecular characteristics of SS subtypes to identify new treatment targets, with innovative approaches including immune-based therapies and epigenetic modifiers being researched.
Associations between subjective well-being (SWB) and dietary habits, employment status, and habitual activities are increasingly capturing the focus of researchers as well as policymakers worldwide. This study aimed to explore these associations in a sample of the population in Greece and Cyprus via an online survey. In total, 936 questionnaires (470: Cyprus, 466: Greece) were analyzed to study the associations between the Mediterranean Diet (MD) (using the 14-item MEDAS score, (14-MEDAS)), subjective well-being (SWB), and several socioeconomic factors.
View Article and Find Full Text PDFIn this study, we described physico-chemical properties of novel nanoformulation of photosensitizer-pyropheophorbide α 17-diethylene glycol ester (XL) (chlorophyll α derivative), revealing insights into antitumor activity and maintaining quality, meeting the pharmaceutical approach of new nanoformulation design. Our formulation, based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles, increased XL solubility and selective tumor-targeted accumulation. In our research, we revealed, for the first time, that XL binding to polyvinyl alcohol (PVA) enhances XL photophysical activity, providing the rationale for PVA application as a stabilizer for nanoformulations.
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