Assessing the emergence time of SARS-CoV-2 zoonotic spillover.

Understanding the evolution of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) and its relationship to other coronaviruses in the wild is crucial for preventing future virus outbreaks. While the origin of the SARS-CoV-2 pandemic remains uncertain, mounting evidence suggests the direct involvement of the bat and pangolin coronaviruses in the evolution of the SARS-CoV-2 genome. To unravel the early days of a probable zoonotic spillover event, we analyzed genomic data from various coronavirus strains from both human and wild hosts.

Using traditional machine learning and deep learning methods for on- and off-target prediction in CRISPR/Cas9: a review.

CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9) is a popular and effective two-component technology used for targeted genetic manipulation. It is currently the most versatile and accurate method of gene and genome editing, which benefits from a large variety of practical applications. For example, in biomedicine, it has been used in research related to cancer, virus infections, pathogen detection, and genetic diseases.

Fast and optimal branch-and-bound planner for the grid-based coverage path planning problem based on an admissible heuristic function.

This paper introduces an optimal algorithm for solving the discrete grid-based coverage path planning (CPP) problem. This problem consists in finding a path that covers a given region completely. First, we propose a CPP-solving baseline algorithm based on the iterative deepening depth-first search (ID-DFS) approach.

Intelligent personalized shopping recommendation using clustering and supervised machine learning algorithms.

Next basket recommendation is a critical task in market basket data analysis. It is particularly important in grocery shopping, where grocery lists are an essential part of shopping habits of many customers. In this work, we first present a new grocery Recommender System available on the MyGroceryTour platform.