[Genetic variability of synthesis feature of carotenoids in Streptomyces globisporus 1912].

Seventeen spontaneous and induced mutants, that acquired a new characteristic--the synthesis of beta-carotene and lycopene, were obtained from strain Streptomyces globisporus 1912. It was found that spontaneous mutants inherited more stably the acquired carotenogenesis as compared to induced ones. Synthesis of carotenoids by all isolated Crt+ Lcp+ cultures is a constitutive feature.

[Quantum-chemical basics of pharmacokinetics (literary review and own investigations)].

The work is devoted to the use of quantum-pharmacological approaches in pharmacokinetic investigations. The main objective of the pharmacological researches is to find new, more active and less toxic drugs. To date, such a search is carried out empirically.

[Bacteriocidal activity of Streptomyces cultures].

Bacteriocidal activity of metabolites synthesized by 17 plasmid-containing cultures of Streptomyces has been studied. These cultures were isolated from soils of Ukraine with different anthropogenic contamination. The cultures, in their majority (85.

[Construction of a new bifunctional vector which contains EGFP-gene].

A number of bifunctional vector structures (pTpE, pTpE5, pTpH2, pTpH7, pTpS1) with molecular dimension of 11.3 kb has been created. Vector plasmids can be replicated, sustainably maintained and expressed both in Gram-negative (Escherichia coli XL1 Blue) and in Gram-positive (Streptomyces levoris 165) cultures.

[Plasmids of streptomycetes strains isolated from soils of Ukraine with different anthropogenic loading].

Screening of plasmid DNA was carried out among 94 streptomycetes cultures which were isolated from the samples of Ukrainian soils with different anthropogenic contamination. Seventeen streptomycetes strains containing plasmid DNA were found. It is established that some cultures contain more than one plasmid (Streptomyces sp.