[Neurotransmitter changes in the rat brain under combined intoxication induced by alcohol and morphine].

We investigated the levels of biogenic monoamines and their metabolites in the rat hypothalamus, midbrain and cerebellum in acute complex intoxication with morphine and alcohol. The distinctive features of neurotransmitter disorders in various parts of the rat brain under a single exposure to ethanol and morphine, as well as the differences between acute morphine-alcohol and alcohol-morphine intoxication were established. Complex intoxication with alcohol and morphine resulted in signs of dopamine consumption only in the hypothalamus, regardless of the order of alcohol and morphine administration.

[Particularities of γ-aminobutyric acid metabolism in the liver of rats during different types of alcohol withdrawal].

Activities of GABA-catabolising enzymes and the contents of some amino acids have been studied in the liver of the rats with different types of alcohol cessation after its systemic administration. Intermittent alcohol intoxication was accompanied by activation of liver GABA catabolism in case of the lowest alcohol load. However ethanol in higher doses and prolongation of intermittent alcohol administration decreased GABA catabolism.

[Correction of metabolic changes in rats with sporadic alcoholic intoxication].

Faltering alcoholic intoxication is accompanied by activation of processes of lipid peroxidation in blood and a liver, and also reduction of levels of a number of amino acids in tissue. Compositions of "Tavamin" and "Neyramin" used for correction show normalizing effect on a pool of free amino acids in a liver and skeletal muscles, and also a number of biochemical characteristics in blood.

Neurotransmitter mechanisms of morphine withdrawal syndrome.

Activity of the major neurotransmitter systems in the brainstem and cerebellum was studied in rats with morphine withdrawal syndrome. The most significant changes were found in the brainstem of animals by the 36th hour and 7 days after morphine withdrawal. Dysfunction was revealed in the dopaminergic, noradrenergic, and serotoninergic neurotransmitter systems.

[Metabolic correction of neurochemical disturbances in the striatum by the amino-acid-based drug tavamin on the experimental model of morphine abstinence syndrome].

We have studied the content of neuroactive amino acids in the striatum of rats under the conditions of development of the morphine abstinence syndrome, as well as the possibility of its metabolic correction by amino-acid-based drug tavamin. Peculiarities in the metabolism of glutamate, aspartate, glycine, GABA, and taurine in addicted rats and the effect of tavamin on the background of abstinence syndrome have been revealed.