[Pharmacokinetic characteristics of 14C-peritol based on data on its distribution in rat tissue].

Peritol (cyproheptadine) is chemically 1-methyl-4-(5-dibenzo-cyclohepta-trenilidin)-piperidine hydrochloride. It has a pronounced antihistamine and antiserotonin action. When injected intravenously to rats 14C-peritol is rapidly excreted from blood (T 1/2 = 2 h).

[Kinetics of accumulation and elimination of 14C-dipine, an antineoplastic drug].

An investigation on evaluating the distribution of 14C-dipine in rats with sarcoma 45 was carried out. With intragastric administration of the drug its resorption occurs largely in the small intestine. The maximally absorbed portion of the tag is detected in 1 hour and by this time it reaches 36.