[Immunogenicity of recombinant proteins including ectodomain of M2 influenza virus A].

Two recombinant proteins with three copies of the ectodomain of the conserved influenza protein M2 (M2e) of influenza viruses were developed: A (H1N1)pdm09, A/Kurgan/05/05 (H5N1), and M2e consensus sequence of the human influenza A virus (H1N1, H2N2, H3N2) based on flagellin and core antigen of hepatitis B (HBc). The first recombinant protein comprised flagellin fused to three tandem copies of M2e, the second preparation was based on non-covalent interaction between M2e peptides and HBc. The immunogenicity of two preparations was comparatively tested.

[Evaluation of morbidity with temporary work disability in a metal treatment enterprise].

The authors present materials about influence of occupational factors on transitory disablement morbidity, exemplified by metal treatment enterprise.

[Study of hepatitis E virus replication in FRhK-4 cell culture].

The cytolytic form of hepatitis E virus reproduction in FRhk-4 cells is described. The cytopathic effect was observed by days 6-7 of the 25th passage in this cell culture. Reverse transcription with polymerase chain reaction were used to study virus reproduction daily for 10 days postinfection.

[Neurovasal relations in the human neocortex].

Different types of interneurons producing nitric oxide in human brain motor cortex were studied by means of histochemical reaction to NADPH diaphorase--the marker of nitric oxide synthase. Non-synaptic dendrito-, axo- and somatovasal contacts between typical smooth and spinous checking interneurons were shown. A hypothetic scheme of local blood circulation control is represented, after which these cells, exerting inhibitory synaptic action on pyramidal neuron at the same time cause vasodilatation by secreting nitric oxide near to the capillary.

[The morphofunctional heterogeneity between peritoneal and alveolar macrophages in their biogenic amine content: the effect of their presence or absence in the microenvironment of mast cells].

Peritoneal macrophages differ from alveolar ones in biogenic amine content: peritoneal macrophages contain smaller amounts of histamine and serotonin. When activated, alveolar macrophages release biogenic amines, whereas in peritoneal macrophages stimulators of macrophage activity induce the increase in amine content. This may be due to the presence of mast cells in their microenvironment macrophage activity.