[Prenatal exposure to sodium oxybutyrate prevents a disorder of general behavior, learning and memory in the progeny of rats subjected to chronic hemic hypoxia].

The hemic hypoxia caused by the methemoglobin-inducing agent sodium nitrite (40 mg/kg intraperitoneally at days 10 to 19 of pregnancy) evokes a decrease in the birth and survival rates of pups, delayed disorders of motor coordination. Prenatal hypoxia was demonstrated to be able to disturb the habituation in the open field, learning and memory in passive avoidance paradigm, cognitive ability in the plus-maze extrapolative water escape test. The treatment of pregnant rats with sodium hydroxybutyrate (150 mg/kg orally 1-3 times daily at days 12 to 19 of pregnancy) normalizes offsprings' birth and survival rates, prevents the above-mentioned neuropsychological disturbances and improves learning in the active avoidance test.

[The behavioral consequences of prenatal hemic hypoxia in rat progeny].

The prenatal hemic hypoxia was caused by methemoglobin inducing agent, sodium nitrite, injected intraperitoneally in different doses from 10th to 19th day of pregnancy. It was shown that perinatal hemic hypoxia evoked delayed neurological deficit (disorders of motor coordination, hypodynamia) and disturbances of mnestic functions (impairment of learning and memory in passive and active avoidance paradigms and in the test of extrapolative water escape). The most pronounced disorders of CNS functions were shown in offsprings of male rats injected with sodium nitrite in a dose of 40 mg/kg.