[The thrombocytic link in hemostasis and the immunity system of patients with HIV infection].

To find out possible relationships between disturbances in the thrombocytic element of hemostasis and in the immune system (the count of lymphocytes CD4, the concentration of IgG, the content of circulating immune complexes), 18 adult patients with HIV infection were examined, and in 8 of them thrombocytopenia was diagnosed. 10 patients without thrombocytopenia formed the control group. The study revealed that with the development of thrombocytopenia in patients with HIV infection the aggregation capacity of their blood platelets decreased, which correlated (p < 0.

[Immune system indices for the prediction of the course of human immunodeficiency virus infection].

In 25 persons having HIV infection with different dynamics of the progress of the disease the content of lymphocyte populations was studied (by the methods of rosette formation and with the use of monoclonal antibodies) and the rosette-forming and functional metabolic activity of neutrophils was determined. In comparison with patients with a stable course of HIV, patients with relatively rapid progress infection were found to have a significantly lesser amount of E-rosette-forming cells (E-RFC), active E-RFC, theophylline resistant E-RFC, E-rosette-forming neutrophils (E-RFN) and active E-RFN in combination with a significantly higher neutrophil and phosphatase activity and a significantly higher content of cation proteins. These characteristics may be used as criteria for prognosis of HIV infection progression.

Immunological evaluation of late complement component-deficient individuals.

The possible contribution of additional immunologic variables to the susceptibility of late complement component-deficient individuals to meningococcal disease has not been systematically examined in previous studies. Thus, we studied three groups of patients: (1) 24 healthy individuals, (2) 8 complement-sufficient individuals with a history of recurrent bacterial meningitis, and (3) 19 complement-deficient individuals with prior meningococcal infection. No statistical differences were noted among the three groups for the following parameters: the absolute number and the percentage of lymphocytes; CD3+, CD4+, CD8+, CD20+, and CD16+ cells; and the CD4+/CD8+ ratio.

[The comparative characteristics of the indices of lymphocyte and neutrophil functional activity in patients with HIV infection and chronic viral hepatitis B].

In 34 patients with human immunodeficiency virus (HIV) infection at the asymptomatic stage and 29 patients with chronic viral hepatitis B at the period of exacerbation (of these 14 patients had chronic persistent hepatitis and 15 patients had chronic active hepatitis) the complex study of the functional activity of lymphocytes and neutrophils was carried out by cytochemical methods with the simultaneous determination of the content of immunoregulating lymphocyte subpopulations. In patients with chronic active hepatitis a decrease in the percentage and the absolute number of helper T-lymphocytes and the ratio of CD4/8 in comparison with those in patients with HIV infection were revealed. At the same time patients with HIV infection exhibited more pronounced decrease in the activity of all lymphocytic enzymes under study (neutrophil esterase, acidic phosphatase and succinate dehydrogenase in lymphocytes), as well as in the activity of myeloperoxidase and the content of cation proteins and glycogen in neutrophils in comparison with patients having chronic active hepatitis.