[The effect of foridon on the cerebral circulation in non-narcotized animals].

In chronic experiments in rabbits, foridone, 0.3 mg/kg, i.v.

[Effect of foridon on the blood supply of the cat brain in health and in intracerebral hemorrhage].

In experiments on anesthetized cats, foridone (1 and 3 micrograms/kg/min intravenously) was found to increase cerebral blood flow by 6-26% with a moderate decrease of systemic arterial blood pressure indicating that the drug possessed properties with respect to a selective cerebral vasodilatator. Phenygidine (0.3-3 micrograms/kg/min) did not exhibit such a property.

[Calcium transport in proteoliposomes incorporating membranes of skeletal muscle T-system].

Using the radioisotope method, the Ca2+ transport through proteoliposomes was investigated. The proteoliposomes originating from total brain lipids and skeletal muscle T-system membranes of the rabbit were shown to possess a Ca2+ permeability which can be stimulated by 1.4-dihydroxypyridine derivatives (10(-9)-10(-7) M).

Preparation and properties of ryodipine, an effective antihypertensive agent.

A novel effective antihypertensive agent, 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl++ +)-1,4-dihydropyridine (ryodipine, PP-1466) has been obtained. A method for ryosidine synthesis has been developed, side products of PP-1466 synthesis have been isolated and identified. Special characteristics (IRS, UVS, NMR, MS) and chromatography data (TLC, HPLC) are cited.