Biomaterial-based scaffolds for direct in situ programming of tumor-infiltrating T lymphocytes.

Adoptive cell therapy with tumor-infiltrating T cells (TILs) has generated exciting clinical trial results for the treatment of unresectable solid tumors. However, solid tumors remain difficult targets for adoptively transferred T cells, due in part to poor migration of TILs to the tumor, physical barriers to infiltration, and active suppression of TILs by the tumor. Furthermore, a highly skilled team is required to obtain tumor tissue, isolate and expand the TILs ex vivo, and reinfuse them into the patient, which drives up costs and limits patient access.

Hypercholesterolemia exacerbates in-stent restenosis in rabbits: Studies of the mitigating effect of stent surface modification with a CD47-derived peptide.

Background And Aims: Hypercholesterolemia (HC) has previously been shown to augment the restenotic response in animal models and humans. However, the mechanistic aspects of in-stent restenosis (ISR) on a hypercholesterolemic background, including potential augmentation of systemic and local inflammation precipitated by HC, are not completely understood. CD47 is a transmembrane protein known to abort crucial inflammatory pathways.

Assessing the impact of COVID-19 on STEM (science, technology, engineering, mathematics) researchers in India.

The coronavirus disease 2019 (COVID-19) pandemic and the nationally mandated lockdown has resulted in facility closures, decreased laboratory activities, and shifting to remote working. The effects of the pandemic have spread across all professions, including academia. Hence, the present study aims to understand the extent of the impact of the COVID-19 pandemic on STEM (science, technology, engineering, mathematics) researchers and stakeholders in India.

Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation.

Degenerative mitral valve (MV) regurgitation (MR) is a highly prevalent heart disease that requires surgery in severe cases. Here, we show that a decrease in the activity of the serotonin transporter (SERT) accelerates MV remodeling and progression to MR. Through studies of a population of patients with MR, we show that selective serotonin reuptake inhibitor (SSRI) use and promoter polymorphism 5-HTTLPR LL genotype were associated with MV surgery at younger age.