[Role of calcium ions in frequency accomodation of rat hippocampal neurons].

Electrophysiological investigations of extracellular Ca ions the influence on the mechanism of frequency accommodation were carried out on isolated rat hippocampal neurones. It is established that interpulse interval during potential generation action linearly depended on quantity of Ca ions, which enter the cell through Ca2+ channels. Analysis of the results has shown that Ca ions influenced the forming and parameters of frequency accommodation in hippocampal neurones, probably via activation of Ca-dependent outward K-currents.

[Immunophenotype of lymphocytes of patients with malignant melanoma and its dynamics during immunotherapy with interleukin-2].

A Mab set was used to study immunological phenotype of lymphocytes of five patients bearing stage IV malignant melanoma and its changes developing in the course of interleukin-2 (Euro cetus) immunotherapy. Patients were shown to have lowered counts of T cells (mainly due to T-helper/inducers), B cells and lymphocytes expressing adhesion and activation molecules as well as abnormal immunoregulatory cell ratio. Two patients receiving interleukin-2 achieved a response.

[Multifactorial analysis in the prognostication of the incidence of recurrences, metastases and survival of patients with squamous cell cancer of the skin].

A retrospective analysis of the data on 116 cases of squamous cell carcinoma of the skin of the body and extremities was undertaken. Eight parameters were found to influence metastasis formation and five-year survival: extent of involvement according to TNM classification, background conditions of tumor development, duration of disease, rate of tumor growth, gross appearance of tumor, site, contour and histologic pattern of malignancy. Recurrence development was influenced by nine parameters including those mentioned above plus extent of surgery.