[The risk of bronchial asthma exacerbations among smokers with asthma-chronic obstructive pulmonary disease overlap after inpatient treatment].

Aim: To assess the risk of exacerbations of bronchial asthma (BA) in smoking patients with the asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) after inpatient treatment.

Materials And Methods: 36 smokers with ACO (main group) and 36 non-smoking patients (control group) with severe or moderate exacerbation of bronchial asthma were examined. Assessment of the severity of exacerbation of BA before treatment, levels of control and risk of exacerbations of BA after treatment was determined according to the Federal clinical guidelines for the diagnosis and treatment of BA (2016).

[Matrix metalloproteinases and clinical and functional status in smokers with persistent asthma].

Aim: To assess the role of matrix metalloproteinases (MMP) in the clinical and functional status of smoking patients with persistent asthma.

Subjects And Methods: Examinations were made in 16 healthy smokers (a control group), 22 healthy nonsmoking volunteers (a volunteer group), and 16 patients with endogenous (n = 6) and mixed (n = 10) persistent asthma (a study group) with varying disease control. The investigators used the following techniques: spirometry; determination of airway resistance and FeCO in the expired air; 30-minute percutaneous monitoring of blood oxygenation and 6-minute walk test; enzyme immunoassay for matrix metalloproteinase levels.

[Evaluation of the degree of respiratory failure in patients with chronic obstructive pulmonary disease].

Thirty practically healthy individuals and 111 patients suffering from chronic obstructive pulmonary disease (COPD) with I to III degree chronic respiratory failure (CRF) were examined. The study established a negative correlation between partial oxygen pressure in arterial blood (AB), the degree of bronchial obstruction, hemoglobin saturation, and the degree of CRF. It was found that the degree of CRF was in a significant correlation with the degree of pulmonary physiological (alveolar) shunt and the degree of hypercapnia.

[Functional state of the diaphragm during several non-drug methods of the treatment of chronic pulmonary insufficiency].

The study compared the effect of conventional therapy of aggravated chronic obstructive bronchitis (COB), inpatient oxygen treatment of large duration (OT), normobaric hypoxic stimulation (NBHS), inspiratory resistance on the diaphragmatic muscle function in COB patients with chronic pulmonary insufficiency. The function was assessed at stimulation electromyography of the diaphragm. The latter reflected enhanced bioelectric activity of the diaphragm in response to OT and inspiratory resistive training as shown by increased time parameters.

[The hospital stage of the long-term oxygen therapy of chronic lung failure in patients with chronic obstructive bronchitis].

The authors analyze the role of the initial inpatient stage of long-term oxygen therapy (LOT) in combined treatment of chronic pulmonary failure in patients with chronic obstructive bronchitis, lung emphysema, and pneumosclerosis. The treatment lasted 30 days both in the main and in the control groups. In addition to basic therapy, the main group patients received 38% O2 for 15 h a day.