Publications by authors named "V V Filonenko"
Despite progress in the high-pressure synthesis of nanodiamonds from hydrocarbons, the problem of controlled formation of fluorescent impurity centers in them still remains unresolved. In our work, we explore the potential of a new precursor composition, a mixture of adamantane with detonation nanodiamond, both in the synthesis of nanodiamonds and in the controlled formation of negatively charged silicon-vacancy centers in such nanodiamonds. Using different adamantane/detonation nanodiamond weight ratios, a series of samples was synthesized at a pressure of 7.
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- Scientists made special antibodies that can find a molecule called CoA in different tests.
- They used these antibodies with another technique to discover many proteins in bacteria and mammals that are changed by CoA, especially when the cells are stressed.
- They found that when cells are exposed to something like hydrogen peroxide, these changes mostly happen in proteins found in the mitochondria, which are the cell's energy factories.
Ribosomal protein S6 kinases belong to a family of highly conserved enzymes in eukaryotes that regulate cell growth, proliferation, survival, and the stress response. It is well established that the activation and downstream signalling of p70S6Ks involve multiple phosphorylation events by key regulators of cell growth, survival, and energy metabolism. Here, we report for the first time the covalent modification of p70S6K1 by coenzyme A (CoA) in response to oxidative stress, which regulates its kinase activity.
View Article and Find Full Text PDFThe Cystine-xCT transporter-Glutathione (GSH)-GPX4 axis is the canonical pathway to protect against ferroptosis. While not required for ferroptosis-inducing compounds (FINs) targeting GPX4, FINs targeting the xCT transporter require mitochondria and its lipid peroxidation to trigger ferroptosis. However, the mechanism underlying the difference between these FINs is still unknown.
View Article and Find Full Text PDFObjective: The aim: To create a three-dimensional simulation mechanical-mathematical model of the biomechanical system "Orthodontic appliance-maxilla", to study peculiarities of the stress-strained state of the maxilla.
Patients And Methods: Materials and methods: A simulation model of the biomechanical system "Orthodontic appliance-maxilla" was created using computed tomography (CBCT) data. Mathematical modeling was used to determine the stress-strain state of the simulation model.