[Effect of monoamine oxidase inhibitors on the phagocytic activity of macrophages].

Preparations studied in this work with the properties of monoaminoxidase (MAO) inhibitors caused a reduction of the phagocytic activity of cells and degeneration of the cell culture. By the extent of the toxic action on the macrophage culture the preparations could be distributed in the following order: chloracizine, chlorpromazine, vetrazine, indopan; biogenic amine serotonin influenced the phagocytic activity of cells only in very high concentrations. Macrophage cultivation in a medium containing MAO inhibitors led to quantitative and qualitative changes in the acid phosphatase granules.