Dual-Functional Implant Based on Gellan-Xanthan Hydrogel with Diopside, BMP-2 and Lysostaphin for Bone Defect Repair and Control of Staphylococcal Infection.

A new dual-functional implant based on gellan-xanthan hydrogel with calcium-magnesium silicate ceramic diopside and recombinant lysostaphin and bone morphogenetic protein 2 (BMP-2)-ray is developed. In this composite, BMP-2 is immobilized on microparticles of diopside while lysostaphin is mixed directly into the hydrogel, providing sustained release of BMP-2 to allow gradual bone formation and rapid release of lysostaphin to eliminate infection immediately after implantation. Introduction of diopside of up to 3% (w/v) has a negligible effect on the mechanical properties of the hydrogel but provides a high sorption capacity for BMP-2.

Physical and chemical properties of soils in Kharkiv (Ukraine).

The purpose of this work is to determine the physical and chemical properties of soils in different regions of Kharkiv (Ukraine) and to explore their impact on the sorption of heavy metal ions: Cu and Zn. It has been established that the soils of gleyic chernozem and typical heavy black earth by their characteristics belong to highly buffer humified soils. According to the increase in the sorption capacity of the soil, it can be arranged in the following row: haplic arenosol < mollic gleyic fluvisol < gleyic chernozem < typical heavy black earth.

[The role of endogenous bioregulators in formation of cardiogenic reflex effects on circulation].

The possible role of endogenous endothelium-derived bioactive substances in organization of cardiogenic depressor reflexes under cardiac receptor stimulation (by veratrine and bradykinin) was investigated in acute experiments on anesthetized rats. The results have shown that endothelium-derived bioactive substances take part in forming of the cardiogenic depressor reflex humoral components of nervous response or nervous modulators. These data contribute to understanding of the role of endogenous endothelium-derived bioactive substances (prostacyclin) and different NOS isoforms in mechanisms of depressor reflex development and species differences in their involvement in reflex vasomotor reactions.

[Efficacy of biological preparations of soybean root nodule bacteria modified with a homologous lectin].

The effect of various biopreparations of the root nodule bacterium Bradyrhizobium japonicum, modified with a homologous lectin, on the virulence of Rhizobia, the nitrogen-fixing activity of root nodules, and the productivity of the soybean (Glycine max (L.) Merr.) was studied.

[Role of nitric oxide in the mechanisms of formation of reflex vasomotor responses].

This review focuses on modem data concerning the role of nitric oxide (NO) in the mechanisms of vasomotor regulation. On the background of the literature data and own experimental results, we have discussed some questions of NO integration into transmission of impulses in central and autonomic nervous system under condition of realization of cardiogenic and sinocarotid pressor and depressor reflexes, reflectory vasomotor responses formation under acute myocardial ischemia. According to literature and own functional and morphological data we suggest species differences in NO participations in mechanisms of reflex self--regulation of circulation.