[Nooklerin (deanoli aceglumas) in the treatment of astenic and cognitive disorders in patients with borderline psychopatological conditions].

Background: This work is devoted to the combined therapy of asthenic syndrome in psychiatric patients due to the importanmce of studies of clinical signs of asthenic disorders and their comorbidity with psychiatric and somatic diseases.

Aim: To evaluate the efficacy and safety of deanoli aceglumas (nooklerin) in treatment of asthenic and cognitive disorders in patients with borderline psychopathological conditions.

Material And Methods: Sixty patients were enrolled in the study (30 patients of the main group and 30 patients of the control group).

[Evolution of the schizophrenic deficit concept].

The relevance of this study is the high prevalence and clinical heterogeneity of deficit states in chronic schizophrenia and schizophrenia spectrum disorders. The study aimed at analyzing negative symptoms in schizophrenia and schizophrenia spectrum disorders from historical and modern perspectives. An analysis of available literature, along with own observations, has been performed.

[Psychogenic depression and endogenous process (to the problem of reactive schizophrenia)].

Objective: To conduct clinical differentiation of stress-induced conditions in schizophrenia and schizophrenia spectrum disorders according to the concept of so-called "Reactive schizophrenia" (J. Berze).

Material And Methods: A sample consisted of 40 patients (14 male, 26 female, mean age 38.

[Personality disorders and depression].

Comorbid relations between personality disorders (PD) of affective and non-affective types (anxiety-hypochondriac character) and depression were analyzed in 35 patients including 13 men (37.1%) and 22 women (62.9%), mean age 49.