Isoflurane can indirectly depress lumbar dorsal horn activity in the goat via action within the brain.

We have examined the response of lumbar dorsal horn cells to a noxious mechanical stimulus during differential delivery of isoflurane to the brain and spinal cord of goats. We hypothesized that isoflurane, acting in the brain, would depress dorsal horn neuronal responses to a noxious mechanical stimulus applied to the hindlimb. Eight goats were anaesthetized with isoflurane and neck dissections performed which allowed cranial bypass.

Isoflurane depresses motoneuron excitability by a direct spinal action: an F-wave study.

Unlabelled: Isoflurane decreases motoneuron excitability as measured by the F wave. It is unknown how much of this effect is direct and how much occurs as the result of an indirect, supraspinal effect. Seven goats were anesthetized with isoflurane, and the carotid arteries and jugular veins were isolated to permit cranial bypass.

Effect of differential delivery of isoflurane to head and torso on lumbar dorsal horn activity.

Background: The spinal cord appears to be the site where anesthetic agents prevent movement in response to noxious stimuli. When isoflurane is differentially delivered to the head and torso (with low torso concentrations), cranial anesthetic requirements increase compared with systemic administration. The aim of the current study was to test the hypothesis that isoflurane action in the brain has descending influences on spinal cord dorsal horn neurons.

[Results of testing the basic questionnaire "SINDI" in the evaluation of prophylaxis program development].

The results are considered of testing questionnaires designed to evaluate the progress in the implementation of the complex prevention programme "CINDI". The questionnaire survey was carried out in two ways--by post and by telephone. The sample size amounted to 248 people each.