Aggressive Regimens Reduce Risk of Recurrence After Successful Treatment of MDR-TB.

Background: We sought to determine whether treatment with a "long aggressive regimen" was associated with lower rates of relapse among patients successfully treated for pulmonary multidrug-resistant tuberculosis (MDR-TB) in Tomsk, Russia.

Methods: We conducted a retrospective cohort study of adult patients that initiated MDR-TB treatment with individualized regimens between September 2000 and November 2004, and were successfully treated. Patients were classified as having received "aggressive regimens" if their intensive phase consisted of at least 5 likely effective drugs (including a second-line injectable and a fluoroquinolone) used for at least 6 months post culture conversion, and their continuation phase included at least 4 likely effective drugs.

Low rates of recurrence after successful treatment of multidrug-resistant tuberculosis in Tomsk, Russia.

Setting: Tomsk, Russia, where multidrug-resistant tuberculosis (MDR-TB) is prevalent.

Objectives: To report rates of recurrence following successful treatment of MDR-TB in a program providing individualized treatment regimens designed according to the current global standard of care.

Design: A retrospective cohort study of 408 adults successfully treated for pulmonary MDR-TB from 10 September 2000 to 1 November 2004, and followed for up to 6 years post-treatment.

[Rocuronium bromide as component of general anaesthesia in patients with traumatic cerebral compression].

The choice of myorelaxation agent for rapid sequence tracheal intubation for surgical cerebral decompression is a less studied question in neuroanaesthesiology. 32 patients with cerebral trauma (GCS<8) were involved in the study. Influence of succinylcholine and rocuronium bromide on cerebral circulation, intracranial pressure, cerebral perfusion pressure and systemic haemodynamics was assessed.

Barriers to successful tuberculosis treatment in Tomsk, Russian Federation: non-adherence, default and the acquisition of multidrug resistance.

Objective: To identify barriers to successful tuberculosis (TB) treatment in Tomsk, Siberia, by analysing individual and programmatic risk factors for non-adherence, default and the acquisition of multidrug resistance in a TB treatment cohort in the Russian Federation.

Methods: We conducted a retrospective cohort study of consecutively enrolled, newly detected, smear and/or culture-positive adult TB patients initiating therapy in a DOTS programme in Tomsk between 1 January and 31 December 2001.

Findings: Substance abuse was strongly associated with non-adherence [adjusted odds ratio (OR): 7.