[Prospects of use of gene therapy in head trauma].

Neuronal injury may have one of the following three sequelae: death of the neurone, persistent atrophy or recovery. The ability of mature neurones to recover is dependent to a not inconsiderable degree on neurotrophins, on the basis of which consideration the following objective of genotherapy in craniocerebral injury (CCI) is formulated: achievement of therapeutically useful levels of expression of neutrophins by employment of genetical methodological approaches. The next prerequisite for institution of genotherapy in CCI is a proved dependance of CCI sequelae on individual genetic features, on APO E-genotype in particular, which fact suggests to us that specific correction is within the bounds of possibility.

[A clinico-biochemical basis for the use of enterosorption in severe craniocerebral trauma].

Particular features were studied of the time course of changes in biochemical parameters characterizing endogenous intoxication in severe craniocerebral injury in patients greater than 45 years old. In group 1 patients displaying high values for endotoxicosis, there has been noted lowering of the above values after enterosorption over the immediate twenty-four hours following the injury, accompanied by regression of neurological symptomatology. In group 2 those who had sustained the injury and had normal or moderately elevated values for endotoxicosis on the first day, the latter were found to be on the increase in the time course of acute period of the injury.