[SQUALENE: PHYSIOLOGICAL AND PHARMACOLOGICAL PROPERTIES].

The review of literature demonstrates that squalene, known to most experts as an intermediate product in the synthesis of cholesterol, has several pharmacological properties including hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity. Squalene is effective in the treatment of diabetes mellitus type 2 and can potentiate the activity of some antitumor (antiblastoma) preparations and reduce their undesired side effects. This bioactive substance has low toxicity and, in therapeutic doses, does not produce any damaging action on the human organism.

[The influence of application of a low-frequency magnetic field on the serum corticosterone level (an experimental study)].

The results of analysis of the literature publications suggest the necessity of experimental studies aimed at investigation of modulating effect of low-frequency magnetic fields on endocrine organs. The present study was carried out using 200 outbred white male rats (body weight 200-220 g). Corticosterone was measured in blood sera following the application of a low-frequency magnetic field (20 and 53 Hz with induction from 0.

[Medium molecular size peptides of blood plasma in diabetes mellitus].

The level of medium molecular peptides (MMP) grows up in blood plasma of patients with diabetes mellitus (DM), which results in endogenous intoxication. The MMP concentration is high in patients with insulin-independent DM at compensation and without renal affection versus insulin-dependent DM, which is explained by presence of 1-3 kDa peptides. An aggravated course of DM including subcompensation is associated with a higher MMP level in patients with both DM types.

[Mean molecule peptides of plasma and blood serum].

The concentration of mean molecule peptides is by far less in serum versus plasma. The concentration of mean molecule peptides in serum can go down, in endotoxicosis degrees 3-4, to normal values, whereas it can exceed 3-4-fold the normal value in plasma. The most pronounced reduction of peptides' concentration in serum was registered for the fraction with the molecular weight ranging from 800 to 3000 D.

[Dependence of myocardial contracture on energy resources during the calcium paradox].

Perfusion of the rat isolated hearts with calcium-free and calcium containing solution revealed a complex and deep myocardial damage called the calcium paradox. The reperfusion of the rat heart with calcium rich media resulted in myoglobin loss from the heart, significant decreasing of ATP and phosphocreatine level, complete uncoupling of respiration and phosphorylation in mitochondria, occurrence of myocardial contracture. Decreasing of sodium level to 30 mM--80 mM in calcium free media exacerbates the heart damage due to the calcium paradox with absence of contracture.