Are the Hematological Parameters Useful in Differentiating Acute Pyelonephritis from Cystitis in Patients with Chronic Kidney Disease?

Background And Objectives: The importance of hematological parameters has started to be explored with increased interest in many fields lately, with different studies finding an association between those parameters and inflammatory status, atherosclerosis, comorbidities, malnutrition, neoplasia and even a faster progression of chronic kidney disease (CKD). On the other hand, CKD itself presents as an inflammatory condition, in which a lot of pathways are modified and the response to an infectious agent could be less than expected. Regarding the latter aspect, in this study we aim to explore the differences between the hematologic response during a lower versus upper urinary tract infection in patients with CKD.

Numerical and Experimental Analysis of Buckling and Post-Buckling Behaviour of TWCFS Lipped Channel Section Members Subjected to Eccentric Compression.

The paper presents a static analysis of the buckling and post-buckling state of thin-walled cold-formed steel (TWCFS) lipped channel section beam-columns subjected to eccentric compression. Eccentricity is taken into consideration relative to both major and minor principal axes. An analytical-numerical solution to the buckling and post-buckling problems is described.

Grading of glioma tumors using digital holographic microscopy.

Gliomas are the most common type of cerebral tumors; they occur with increasing incidence in the last decade and have a high rate of mortality. For efficient treatment, fast accurate diagnostic and grading of tumors are imperative. Presently, the grading of tumors is established by histopathological evaluation, which is a time-consuming procedure and relies on the pathologists' experience.

Image-Compression Techniques: Classical and "Region-of-Interest-Based" Approaches Presented in Recent Papers.

Image compression is a vital component for domains in which the computational resources are usually scarce such as automotive or telemedicine fields. Also, when discussing real-time systems, the large amount of data that must flow through the system can represent a bottleneck. Therefore, the storage of images, alongside the compression, transmission, and decompression procedures, becomes vital.

Metabolic reprogramming of immune cells by mitochondrial division inhibitor-1 to prevent post-vascular injury neointimal hyperplasia.

Background And Aims: New treatments are needed to prevent neointimal hyperplasia that contributes to post-angioplasty and stent restenosis in patients with coronary artery disease (CAD) and peripheral arterial disease (PAD). We investigated whether modulating mitochondrial function using mitochondrial division inhibitor-1 (Mdivi-1) could reduce post-vascular injury neointimal hyperplasia by metabolic reprogramming of macrophages from a pro-inflammatory to anti-inflammatory phenotype.

Methods And Results: In vivo Mdivi-1 treatment of Apoe mice fed a high-fat diet and subjected to carotid-wire injury decreased neointimal hyperplasia by 68%, reduced numbers of plaque vascular smooth muscle cells and pro-inflammatory M1-like macrophages, and decreased plaque inflammation, endothelial activation, and apoptosis, when compared to control.