Publications by authors named "V Tyrrell"
Enzymatically oxygenated phospholipids (eoxPL) from lipoxygenases (LOX) or cyclooxygenase (COX) are prothrombotic. Their generation in arterial disease, and their modulation by cardiovascular therapies is unknown. Furthermore, the Lands cycle acyl-transferases that catalyze their formation are unidentified.
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- Embedding precision medicine in pediatric oncology aims to improve treatment for children with cancer, showing promising potential for future care.
- The first comprehensive study in Australia evaluates the costs associated with implementing precision medicine for high-risk childhood cancers, specifically through the Zero Childhood Cancer Precision Medicine Programme.
- The estimated costs in 2021 Australian dollars are $12,743 per patient for access, $14,262 for identifying the molecular cause, and $21,769 for making recommendations, providing valuable insights for clinical management strategies.
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- Scientists from 34 labs in 19 countries worked together to measure certain fats (ceramides) in human blood using special techniques.
- They used both standard methods and their own methods to get very accurate and consistent results.
- The study helps improve future medical tests and treatments by providing reliable information about these fats in blood samples.
Oxidized phospholipids (oxPLs) are generated during innate immunity and inflammation, where they play a variety of biological roles, including regulation of autoimmunity and coagulation. Some are generated by enzymatic reactions, leading to stereo- and regiospecificity, while many others can be formed through nonenzymatic oxidation and truncation and can be used as biomarkers of oxidative stress. Mass spectrometry methods have been developed over many years for oxPL analysis, which can provide robust estimations of molecular species and amounts, where standards are available.
View Article and Find Full Text PDFBackground: Clotting, leading to thrombosis, requires interactions of coagulation factors with the membrane aminophospholipids (aPLs) phosphatidylserine and phosphatidylethanolamine. Atherosclerotic cardiovascular disease (ASCVD) is associated with elevated thrombotic risk, which is not fully preventable using current therapies. Currently, the contribution of aPL to thrombotic risk in ASCVD is not known.
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