Changes of locomotor, exploratory and emotional behavior in animal model of depression induced by deficiency of brain monoamine content.

The character of changes of open field behavior was not studied extensively in animal model of depression with deficiency of brain monoamine/serotonin content and obtained results are controversial. Both, enhancement and invariability of locomotor activity has been obtained. Additional investigation of this question is motivated also by insufficient study of exploratory and emotional behaviors in animal model of depression of this type.

Nucleus- and species-specific properties of the slow (<1 Hz) sleep oscillation in thalamocortical neurons.

The slow (<1 Hz) rhythm is an electroencephalogram hallmark of resting sleep. In thalamocortical neurons this rhythm correlates with a slow (<1 Hz) oscillation comprising recurring UP and DOWN membrane potential states. Recently, we showed that metabotropic glutamate receptor activation brings about an intrinsic slow oscillation in thalamocortical neurons of the cat dorsal lateral geniculate nucleus in vitro which is identical to that observed in vivo.