Expression of phosphorylated Akt, mTOR and MAPK in type I endometrial carcinoma: clinical significance.

Background/aim: The Akt/mTOR and MAPK pathways are frequently activated in various tumor types but data on endometrial carcinoma are limited. The aim of the present study was to investigate the clinical significance of the expression of phosphorylated MAPK, Akt and mTOR (p-MAPK, p-Akt, p-mTOR) in type I endometrial carcinoma.

Materials And Methods: The study comprised of 103 formalin-fixed paraffin-embedded (FFPE) type I endometrial carcino ma cases, retrospectively retrieved and assessed by immuno histochemistry for p-MAPK, p-Akt and p-mTOR expression.

The prognostic role of preoperative serum CA 125 levels in patients with endometrial carcinoma.

Purpose: Previous studies have shown that elevated preoperative serum CA 125 levels strongly correlate with various clinical and pathological variables and prognosis of patients with endometrial carcinoma (EC). The aim of the present study was to evaluate the clinical significance of preoperative serum CA 125 levels in patients with EC.

Methods: A retrospective study of all EC patients treated at our institution between 1995 and 2010 with available follow-up was conducted.

Transvaginal ultrasound-guided aspiration of benign ovarian cysts.

In our study, we evaluate the diagnostic and therapeutic efficacy of transvaginal ultrasound-guided aspiration of benign ovarian cysts in selected patients. A total of 46 women with benign ovarian cysts were referred to our outpatient clinic. The aspirated fluid was collected and sent for cytological analysis.

Coexistence of three benign and a borderline tumor in the ovaries of a 52-year-old woman.

Purpose Of Investigation: In this paper, the authors describe a rare case of four simultaneous ovarian tumors.

Materials And Methods: A 52-year-old postmenopausal woman underwent total hysterectomy and bilateral salpingo-ophorectomy. Multiple slides from the ovaries were examined.