Publications by authors named "V Thiyagarajan"

Global changes can profoundly affect the sex determination and reproductive output of marine organisms, disrupting the population structure and ecosystems. High COdriven low pH in the context of ocean acidification (OA) has been shown to severely affect various calcifiers, but less is known about the extent to which low pH influences sex determination and reproduction of marine organisms, particularly mollusks. This study is the first to report a biased sex ratio over multiple generations toward females, driven by exposure to high CO-induced low pH environments, using the ecologically and economically important Portuguese oyster () as a model.

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Article Synopsis
  • - Producing accurate 3D models from biological images, especially of complex brain structures, requires extensive human effort to annotate data, which is time-consuming and typically done by experts.
  • - The authors developed a new deep learning method that allows for quick 3D segmentations using minimal 2D annotations, dramatically reducing the time required to create training data.
  • - This innovative approach enables non-experts to generate necessary annotations efficiently, making it easier to study brain circuits and their connections across larger datasets.
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Background: Enteric infections are hypothesized to be associated with intussusception in children. A small increase in intussusception following rotavirus vaccination has been seen in some settings. We conducted post-marketing surveillance for intussusception following rotavirus vaccine, Rotavac introduction in India and evaluated association of intussusception with enteric pathogens.

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Producing dense 3D reconstructions from biological imaging data is a challenging instance segmentation task that requires significant ground-truth training data for effective and accurate deep learning-based models. Generating training data requires intense human effort to annotate each instance of an object across serial section images. Our focus is on the especially complicated brain neuropil, comprising an extensive interdigitation of dendritic, axonal, and glial processes visualized through serial section electron microscopy.

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  • The study presents a novel approach to deep inspiratory breath-hold (DIBH) radiotherapy for left-sided breast cancer using a specially designed frame and manual gating to minimize cardiac exposure.
  • Results showed a significant reduction in cardiac dose with DIBH compared to conventional free-breathing techniques, with heart dose reduced by 34% and various cardiac substructures receiving lower doses.
  • The workflow enhances patient safety and treatment precision, with no observed recurrences in patients during a 9-month follow-up period, demonstrating its efficacy in this clinical setting.
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