Predictive Modeling of Heart Rate from Respiratory Signals at Rest in Young Healthy Humans.

Biological signals such as respiration (RSP) and heart rate (HR) are oscillatory and physiologically coupled, maintaining homeostasis through regulatory mechanisms. This report models the dynamic relationship between RSP and HR in 45 healthy volunteers at rest. Cross-correlation between RSP and HR was computed, along with regression analysis to predict HR from RSP and its first-order time derivative in continuous signals.

[Tuberculosis Profile in Chile: Effect of Migration, Overcrowding and Income on Tuberculosis and Its Spatial Distribution].

Aim: To analyze tuberculosis (TB) incidence, demographic profiles, and associated risk factors in migrant and national populations, in order to understand the impact of migration, overcrowding, and socioeconomic factors on TB prevalence and care-seeking behaviors.

Material And Methods: Data from various communes within the Metropolitan Region and other parts of the national territory were analyzed to assess TB incidence, demographic characteristics, and care-seeking behaviors among migrant and national populations.

Results: TB disproportionately affects males in both migrant and national populations.

Unveiling the hidden electroencephalographical rhythms during development: Aperiodic and Periodic activity in healthy subjects.

Objective: The study analyzes power spectral density (PSD) components, aperiodic (AP) and periodic (P) activity, in resting-state EEG of 240 healthy subjects from 6 to 29 years old, divided into 4 groups.

Methods: We calculate AP and P components using the (Fitting Oscillations and One-Over-f (FOOOF)) plugging in EEGLAB. All PSD components were calculated from 1-45 Hz.

Short-term exercise counteracts accelerated ageing impacts on physical performance and liver health in mice.

Senescence impairs liver physiology, mitochondrial function and circadian regulation, resulting in systemic metabolic dysregulation. Given the limited research on the effects of combined exercise on an ageing liver, this study aimed to evaluate its impact on liver metabolism, circadian rhythms and mitochondrial function in senescence-accelerated mouse-prone 8 (SAMP8) and senescence-accelerated mouse-resistant 1 (SAMR1) mice. Histological, reverse transcription quantitative polymerase chain reaction (RT-qPCR) and immunoblotting analyses were conducted, supplemented by transcriptomic data sets and AML12 hepatocyte studies.

SGLT2i and GLP1-RA exert additive cardiorenal protection with a RAS blocker in uninephrectomized db/db mice.

Introduction: Diabetic Kidney Disease (DKD) is the main cause of end-stage renal disease in the developed world. The current treatment of the DKD with renin-angiotensin system (RAS) blockade does not totally halt the progression to end stage kidney disease. Currently, several drugs have shown to delay DKD progression such as sodium-glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like-1 receptor agonists (GLP-1RA).