Unveiling the Complexity of Rearrangements in Acute Myeloid Leukemias with Optical Genome Mapping.

rearrangements are major genetic entities in the classification of acute myeloid leukemias (AMLs), but their diverse and frequently cryptic nature makes their detection and characterization challenging. Karyotypic anomalies at the locus and/or abnormal Fluorescence in situ hybridization (FISH) results strongly indicate a fusion, but the identification of the translocation partner gene often requires further investigation. partial tandem duplications (PTDs), on the other hand, are undetectable by standard cytogenetics methods.

Student Medical Education Masterclasses: Diversifying the Academic Pipeline.

Background: There remains a lack of diversity among those pursuing clinical academic careers. Structural inequalities, discrimination and a paucity of relatable role models can disadvantage minoritised students, hindering their educational experiences and career opportunities. Innovative and effective approaches are needed at an undergraduate level to address this problem, ensuring the pipeline is representative, diverse and inclusive.

Safety and Prognostic Factor for Survival in Patients with PleurX Drain for Malignant Ascites: AscitX Study.

Malignant ascites (MA) represents 10% of all causes of ascites and is associated with a poor prognosis. The PleurX tunneled peritoneal catheter is a device that allows the management of MA at home in a palliative care context (renamed AscitX catheter for this work). The objective of this study was to analyze real-world data of AscitX use for cancer patients with MA, to describe complications associated with the insertion of this device, and to identify factors influencing patient outcomes.

Five years in the community dental service: clinicians' perspectives.

Introduction Community dentists in England treat patients classed as vulnerable. The services in which they operate have faced challenges, with these known to have affected clinicians. It is important to monitor and understand the workforce and the effect the healthcare landscape, and its changes, has on them and the service they provide.

Identification of Food Spoilage Fungi Using MALDI-TOF MS: Spectral Database Development and Application to Species Complex.

Fungi, including filamentous fungi and yeasts, are major contributors to global food losses and waste due to their ability to colonize a very large diversity of food raw materials and processed foods throughout the food chain. In addition, numerous fungal species are mycotoxin producers and can also be responsible for opportunistic infections. In recent years, MALDI-TOF MS has emerged as a valuable, rapid and reliable asset for fungal identification in order to ensure food safety and quality.