Immobilization of aminothiols on poly(oxyalkylene phosphates). Formation of poly(oxyethylene phosphates)/cysteamine complexes and their radioprotective efficiency.

The necessity to apply near-toxic amounts of radioprotective drugs to achieve adequate protection during radiation treatments represents a major problem in human medicine. One of the promising strategies to suppress the toxicity of these drugs involves their incorporation into biocompatible polymers. In this study cysteamine (Cy) was attached to poly(oxyethylene phosphate), POEP, via an ionic bond.

[Lipid peroxidation in chronic lead exposure].

The state of lipid peroxidation, monitored by MDA concentration in the blood plasma of 46 battery workers with lead level in the blood in the 1.26-5.6 mol/l range is investigated.

[The lipid peroxidation level and antioxidant status of the plasma in patients operated on under propofol (Diprivan) anesthesia].

It has been investigated the level of lipid peroxidation and antioxidant status of blood plasma from patients operated under general anaesthesia with propofol (Diprivan). The following parameters have been registered: TBA-reactive substances (TBARS) and fluorescent lipofuscine-like lipid peroxidation products, before, directly after and 24 hours after anaesthesia. It was not shown statistically significant changes of TBARS before and after anaesthesia.

[The antiradiation properties of betamide under conditions of sublethal and lethal gamma irradiation].

Bone marrow cellularity in the femur, mass and cellularity of the spleen and small intestine, and nucleic acid concentration in the leukocyte mass of blood were investigated after the intraperitoneal administration of betamide (500 mg/kg) 15 min before gamma irradiation of mice with doses of 4, 7 and 9 Gy. The number of myelokaryocytes and splenocytes in the protected animals was shown to exceed considerably that in the controls on days 3 and 9 after irradiation with the three doses. With betamide injected on day 9 following irradiation the number of nucleated cells of the small intestine was larger and the nucleic acid concentration in leukocytes higher than the same indices in the irradiated control.

[Radiation injuries to mice in relation to the modes of administration of adeturon].

In experiments with mice the influence of adeturon, a preparation obtained in Bulgaria, on the survival rate, leucocytes dynamics, cellularity of bone marrow and spleen, and on nucleic acids in the peripheral blood has been investigated. The comparative analysis of the results obtained indicates that the protective and therapeutic administration of adeturon is more effective than a single injection of the drug immediately after irradiation.