Publications by authors named "V Tekus"
Introduction: Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, imaging, and morphological techniques.
Methods: Knee OA was induced by intraarticular MIA injection (0.
Article Synopsis
- A workshop took place in Liverpool for two days to talk about research on disorders caused by autoantibodies.
- Twenty-two speakers and 14 participants shared knowledge and discussed future plans related to these disorders.
- They talked about experiments using rodents to study how autoantibodies affect symptoms and discussed possible treatments to reduce these antibodies.
Cocaine- and amphetamine-regulated transcript (CART) peptides are involved in several physiological and pathological processes, but their mechanism of action is unrevealed due to the lack of identified receptor(s). We provided evidence for the antihyperalgesic effect of CART(55-102) by inhibiting dipeptidyl-peptidase 4 (DPP4) in astrocytes and consequently reducing neuroinflammation in the rat spinal dorsal horn in a carrageenan-evoked inflammation model. Both naturally occurring CART(55-102) and CART(62-102) peptides are present in the spinal cord.
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- Complex Regional Pain Syndrome (CRPS) is characterized by severe chronic pain and hypersensitivity following a minor injury, highlighting the urgent need for better treatments.
- A study using a mouse model identified 125 genes in the dorsal root ganglia that are involved in immune and inflammatory responses, particularly linked to cytokines and neuropeptides.
- Pathway analysis indicated that TNF and JAK-STAT signaling are significant in CRPS, with treatments using etanercept and tofacitinib showing promise in reducing pain-related symptoms in this model.
Hydrogen sulfide (HS) has been shown in previous studies to cause hypothermia and hypometabolism in mice, and its thermoregulatory effects were subsequently investigated. However, the molecular target through which HS triggers its effects on deep body temperature has remained unknown. We investigated the thermoregulatory response to fast-(NaS) and slow-releasing (GYY4137) HS donors in C57BL/6 mice, and then tested whether their effects depend on the transient receptor potential ankyrin-1 (TRPA1) channel in knockout () and wild-type () mice.
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