Publications by authors named "V Tagalakis"

Background: Computed tomography pulmonary angiogram and lung scintigraphy with ventilation/perfusion scan are needed to diagnose pulmonary embolism (PE) in pregnancy. Their associated ionizing radiation doses are considered safe in pregnancy. A standardized patient information tool may improve patient counseling and reduce testing hesitancy.

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Importance: Systematic data on the association between anticancer therapies and thromboembolic events (TEEs) in patients with COVID-19 are lacking.

Objective: To assess the association between anticancer therapy exposure within 3 months prior to COVID-19 and TEEs following COVID-19 diagnosis in patients with cancer.

Design, Setting, And Participants: This registry-based retrospective cohort study included patients who were hospitalized and had active cancer and laboratory-confirmed SARS-CoV-2 infection.

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Article Synopsis
  • The study investigates the risk of venous thromboembolism (VTE) associated with sodium-glucose cotransporter 2 inhibitors (SGLT2Is) compared to dipeptidyl peptidase 4 inhibitors (DPP-4Is) for patients with type 2 diabetes.
  • Using a large database, researchers matched users of SGLT2Is and DPP-4Is and analyzed VTE risk through Cox proportional hazard models.
  • Results indicated that SGLT2Is did not significantly increase the risk of VTE compared to DPP-4Is, suggesting a potentially lower risk, which provides some reassurance regarding the safety of SGLT2Is.
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Background: The use of direct oral anticoagulants (DOACs) in obese patients is uncertain. It is unclear if body mass index (BMI) affects the safety and efficacy of DOACs for the primary prevention of venous thromboembolism (VTE) in high-risk ambulatory patients with cancer. We sought to determine the outcomes associated with the use of apixaban for the primary prevention of cancer-associated VTE according to BMI.

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