Maternal hyperphenylalaninemias in healthy Czech population of pregnant women: 30 years experience with screening, prevention and treatment.

Introduction: The increased level of phenylalanine (Phe) in maternal blood--hyperphenylalaninemia (mHPA) has a detrimental effect on the early development of healthy foetus (1965). The toxic effect causes spontaneous abortion or retards intrauterine growth, skeletal malformation, cardiac anomalies can appear. However the most frequent are microcephaly, mental retardation and hypotrophy.

[Helicobacter heilmanii, a spiral bacterium, in gastric mucosa biopsies].

Interest in possible microbiological causes of gastritis has increased significantly since the discovery of Helicobacter pylori (Hp). Recently a spiral bacterium named Helicobacter heilmannii (Hh) was described in association with chronic gastritis in adult and pediatric patients. Comparisons between these two organisms, as well as the literature on Hh, have also been reviewed.

[Value of peroperative biopsy in the diagnosis and treatment of musculoskeletal tumors.].

In the period 1982-1992 the authors have performed 1276 peroperative biopsies from frozen sections in 607 patients with suspect diagnosis of a musku-loskeletal tumor. In 174 a diagnosis of a primary malignant tumor was established, in 166 of a benigne tumor, in 53 of metastasis, in 104 of a tumor-like lesion, in 33 of an inflamation. In 77 patients (12,6 %) it was not possible to establish peroperatively the diagnosis and it became necessary to wait for the definite histological examination.