Increase in the Incidence of Type 2 Diabetes in Young Children During the COVID-19 Pandemic.

Objective: To describe the incidence of new onset type 2 diabetes (T2D) among children younger than 11 years old diagnosed during the COVID-19 pandemic (March 1, 2020-December 31, 2021) compared to those diagnosed during the pre-pandemic period (January 1, 2017-February 29, 2020) and to compare the metabolic parameters of those with T2D diagnosed before age 11 years with those diagnosed after age 11 years.

Methods: We conducted a retrospective cohort study of youth <21 years with new onset T2D treated at Hasbro Children's Hospital between January 1, 2017 and December 31, 2021. Patients diagnosed at age <11 years were compared to those ≥11 years.

Storage properties of a quantum perceptron.

Driven by growing computational power and algorithmic developments, machine learning methods have become valuable tools for analyzing vast amounts of data. Simultaneously, the fast technological progress of quantum information processing suggests employing quantum hardware for machine learning purposes. Recent works discuss different architectures of quantum perceptrons, but the abilities of such quantum devices remain debated.

Pathophysiology of Cystic Fibrosis Liver Disease.

Hepatobiliary complications of Cystic Fibrosis (CF) constitute a significant burden for persons with CF of all ages, with advanced CF liver disease in particular representing a leading cause of mortality. The causes of the heterogeneity of clinical manifestations, ranging from steatosis to focal biliary cholestasis and biliary strictures, are poorly understood and likely reflect a variety of environmental and disease-modifying factors in the setting of underlying CFTR mutations. This review summarizes the current understanding of the pathophysiology of hepatobiliary manifestations of CF, and discusses emerging disease models and therapeutic approaches that hold promise to impact this important yet incompletely addressed aspect of CF care.

Topological Bogoliubov Quasiparticles from Bose-Einstein Condensate in a Flat Band System.

For bosons with flat energy dispersion, condensation can occur in different symmetry sectors. Here, we consider bosons in a kagome lattice with π-flux hopping, which, in the presence of mean-field interactions, exhibit degenerate condensates in the Γ and the K point. We analyze the excitation above both condensates and find strikingly different properties: For the K-point condensate, the Bogoliubov-de Gennes (BdG) Hamiltonian has broken particle-hole symmetry and exhibits a topologically trivial quasiparticle band structure.

Safety and Durability of Accelerated Infliximab Dosing Strategies in Pediatric IBD: A Single Center, Retrospective Study.

Objectives: Infliximab (IFX) is commonly used to treat children with inflammatory bowel disease (IBD). We previously reported that patients with extensive disease started on IFX at a dose of 10 mg/kg had greater treatment durability at year one. The aim of this follow-up study is to assess the long-term safety and durability of this dosing strategy in pediatric IBD.