Publications by authors named "V T C Carneiro"
Structural characterization, cytotoxicity, antibiofilm activity, and synergistic potential with molecular docking analysis of ibuprofen-derived hydrazide against bacterial pathogens.
Microb Pathog
February 2025
The study investigates the synthesis, characterization, and antibacterial activity of an ibuprofen-derived hydrazide (HIDZ). It was synthesized and characterized using NMR spectroscopy, DFT Calculations, and ADMET studies. Furthermore, HIDZ cytotoxicity on L929 cells was evaluated using the MTT reduction assay.
View Article and Find Full Text PDFHeart function enhancement by an Nrf2-activating antioxidant in acute Y-strain Chagas disease, but not in chronic Colombian or Y-strain.
PLoS Negl Trop Dis
November 2024
Oxidative stress promotes T. cruzi growth and development of chronic Chagas heart dysfunction. However, the literature contains gaps that must be fulfilled, largely due to variations in parasite DTU sources, cell types, mouse strains, and tools to manipulate redox status.
View Article and Find Full Text PDFAim: To compare lumbar X-ray and magnetic resonance imaging (MRI) findings, and to identify the factors associated with joint instability in cases with lumbar spondylolisthesis.
Material And Methods: We performed a retrospective and observational study of patients with a confirmed diagnosis of lumbar or lumbosacral low-grade spondylolisthesis at a single level. Preoperative X-ray and MRI examinations were evaluated.
Article Synopsis
- COVID-19, caused by the SARS-CoV-2 virus, can range from mild to severe, with significant clinical complications linked to excessive immune responses and high levels of pro-inflammatory cytokines.
- This study investigated two gene variants, rs2494746 and rs1130214, in relation to severe COVID-19 outcomes, analyzing samples from 508 infected individuals to assess cytokine levels and genetic information.
- Findings revealed that the rs2494746-C allele is associated with worse disease outcomes, including increased severity, ICU admissions, and mortality, contributing valuable insights into how genetic factors affect immune responses to COVID-19.
Guidelines of the Brazilian Society of Surgical Oncology for anatomopathological, immunohistochemical, and molecular testing in female tumors.
J Surg Oncol
September 2024
Introduction: Precision medicine has revolutionized oncology, providing more personalized diagnosis, treatment, and monitoring for patients with cancer. In the context of female-specific tumors, such as breast, ovarian, endometrial, and cervical cancer, proper tissue collection and handling are essential for obtaining tissue, immunohistochemical (IHC), and molecular data to guide therapeutic decisions.
Objectives: To establish guidelines for the collection and handling of tumor tissue, to enhance the quality of samples for histopathological, IHC, genomic, and molecular analyses.