Publications by authors named "V Strnadova"
Article Synopsis
- GPR10 and NPFFR2 receptors are crucial for controlling food intake and energy balance, and studying their ligands can help create treatments for obesity.
- Double knockout (dKO) mice, which lack both receptors, were tested on standard and high-fat diets to understand the metabolic effects of their deficiency, showing issues like glucose intolerance and insulin resistance.
- The dKO males gained more weight due to higher caloric intake, while dKO females showed obesity and anxiety-like behavior, highlighting the need to investigate these receptor pathways for anti-obesity therapies.
Since 1975, the incidence of obesity has increased to epidemic proportions, and the number of patients with obesity has quadrupled. Obesity is a major risk factor for developing other serious diseases, such as type 2 diabetes mellitus, hypertension, and cardiovascular diseases. Recent epidemiologic studies have defined obesity as a risk factor for the development of neurodegenerative diseases, such as Alzheimer's disease (AD) and other types of dementia.
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- RF-amide peptides play a key role in various physiological processes including appetite regulation, stress response, behavior, and reproductive functions.
- The study focused on neuropeptide FF receptors (NPFFR1 and NPFFR2) by creating lipidized analogs of neuropeptide AF (NPAF) and a stable analog of neuropeptide FF, 1DMe, and testing their effects on food intake in mice.
- While acute administration of oct-NPAF and oct-1DMe reduced food intake in fasted mice, neither had long-term effects on food consumption or body weight in diet-induced obesity. However, oct-1DMe was linked to anxiety-like behavior and changes in hormone levels.
Alzheimer's disease (AD) is a progressive brain disorder characterized by extracellular amyloid-β (Aβ) plaques, intracellular neurofibrillary tangles formed by hyperphosphorylated Tau protein and neuroinflammation. Previous research has shown that obesity and type 2 diabetes mellitus, underlined by insulin resistance (IR), are risk factors for neurodegenerative disorders. In this study, obesity-induced peripheral and central IR and inflammation were studied in relation to AD-like pathology in the brains and periphery of APP/PS1 mice, a model of Aβ pathology, fed a high-fat diet (HFD).
View Article and Find Full Text PDFA previous study on neuropeptide FF receptor 2 (NPFFR2)-deficient mice has demonstrated that NPFFR2 is involved in the control of energy balance and thermogenesis. Here, we report on the metabolic impact of NPFFR2 deficiency in male and female mice that were fed either a standard diet (STD) or a high-fat diet (HFD) and each experimental group consisted of ten individuals. Both male and female NPFFR2 knockout (KO) mice exhibited severe glucose intolerance that was exacerbated by a HFD diet.
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